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WHO Misoprostol Approval Means Lifesaving Treatment for Women in Low-resource Settings

By: Lindsay Grenier, Maternal Health Technical Advisor, MCSP ; Susan Moffson, MCSP Senior Program Officer

This post has been slightly edited from it’s original posting on the blog of the Maternal and Child Survival Program.

A young woman arrived at a health clinic in Sierra Leone with heavy bleeding. She was suffering from postpartum hemorrhage (PPH)—or excessive bleeding after birth—the most common cause of death for women after delivery.

The midwife at the clinic acted quickly, administering oxytocin, a uterotonic that helps the uterus contract to stop the bleeding. However, the facility was lacking the refrigeration needed to properly store the drug, which was also two years out of date. As a result, the oxytocin had no effect, and the woman died two hours later.

mother baby india PPH post partum hemorrhage misoprostol maternal mortality sierra leone MCSP USAID

Mother and newborn in Allahabad, India. (Kate Holt/MCHIP)

Tragically, poor and marginalized populations suffering from a disproportionate burden of disease often have the least access to high-quality health services. This is especially true of women during childbirth, who often deliver at home instead of health facilities. Those women who do make it to a facility may find them ill-equipped, lacking skilled personnel and essential medicines. Or, as in the case of the young woman from Sierra Leone, the medicines may be expired and improperly stored, thereby greatly diminishing their effectiveness.

Alarmingly, all of these women will be at risk of dying from PPH without access to uterotonics. And while oxytocin is the gold standard for preventing and treating PPH, it is not always available or kept sufficiently cool. It must also be given through injection by a skilled birth attendant, such as a doctor or nurse.

Thankfully, there is a second-line uterotonic drug that can be used to prevent and treat PPH when oxytocin is not available: misoprostol. The World Health Organization (WHO) recently added misoprostol — which does not require refrigeration and can be taken as a pill — to the Essential Medicines List for treatment of PPH in every country. This action expands the range of options to treat PPH, empowering health care workers with one more tool in their arsenal to fight bleeding after birth.

As professionals who work every day around the world to ensure our interventions reach the most vulnerable populations, and understand the endorsement of misoprostol means more equitable access to and appropriate use of uteronics for countless women across the developing world.

The WHO announcement opens an exciting new chapter in global health. While much work remains before every facility can guarantee a stable stock of viable oxytocin, the endorsement of misoprostol for the treatment of PPH will increase the availability of lifesaving care for some of the world’s most vulnerable women.

As part of our own comprehensive PPH strategy, MCSP continues to strengthen essential health system functions, with the goal of overcoming local system barriers to provision of high-quality care, effective referral systems, and trained providers.

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