In this “Technical Guidance on the Prevention and Control of Malaria in Africa” answers are given to frequently asked technical questions about how best to prevent malaria infection, to treat malarial illness and to protect women during pregnancy. Bibliographical references and web linkages for additional information are provided. While each Question and Answer is organized around a specific area of intervention (treatment, prevention, etc.), it is important for malaria control programs to support a comprehensive package of preventive and curative services. This “package” approach is key to realizing the full potential of these interventions and to reducing the burden of malaria.