According to the 2020 UNAIDS Report, HIV and AIDS were the leading causes of death among women of reproductive age around the world. Every week, around 6,000 women aged 15 to 24 years acquire HIV. While estimates differ depending on particular global contexts, HIV treatment has been scaled up in the past decades; by mid-2019 there were more than 24 million people living with HIV on treatment, including at least 13 million women aged 15 years and over. Women and girls in sub-Saharan Africa, the world’s region with the largest HIV epidemics, are particularly affected: in 2018, women accounted for 59% of new infections among adults over 15 years in the region, and figures have remained unchanged since 1995.
HIV and AIDS influences the risk of maternal death through a variety of mechanisms. Pregnancy and HIV and AIDS both increase women’s susceptibility to acquiring malaria, with potentially serious drug interactions that hamper effective treatment for both infections. Having an HIV-positive status is associated with negative health outcomes, including increased risk of intrauterine infection. Additionally, proactive measures must be taken to prevent vertical transmission of HIV from mothers to their babies during pregnancy, delivery and breastfeeding.
While progress has been made towards increasing HIV-testing during pregnancy and providing antiretroviral therapy (ART) to prevent vertical mother-to-child transmission, insufficient integration of HIV services into reproductive, maternal, newborn, child and adolescent health care is a major challenge. Pregnancy is a timely opportunity to engage women with needed services for their health and that of their unborn child. Yet the costs of antenatal care and delivery services can prevent expecting mothers from seeking this care. Across Africa, Asia, Latin America and the Caribbean, more than 5 million families spend over 40% of their household expenses on maternal health services every year. Antenatal care represents an important opportunity to screen for, prevent and treat chronic diseases such as HIV and AIDS; however, many women who test positive for HIV during pregnancy do not receive the follow-up care that they need.
Documented barriers to women beginning and continuing HIV treatment include parental consent for adolescent girls; a lack of knowledge about the benefits of ART; psychological factors such as shock, denial and fear of treatment or side effects; financial constraints; HIV and AIDS-related stigma, discrimination, or violence; apprehension about HIV-status disclosure; lack of social support from partners and family; and judgmental encounters with healthcare providers. Broader health system issues such as poor quality of care and social determinants including geographic and economic barriers are also associated with poor uptake and retention.
Reducing HIV and AIDS-related stigma and gender discrimination, including violence against women, increasing family and social support for HIV-positive women during and after pregnancy, training healthcare providers to provide nonjudgmental, compassionate care, and mobilizing communities to promote respectful, high quality, integrated HIV and maternal newborn health services are promising strategies for preventing maternal deaths caused by HIV and AIDS.
Resources
Key Papers
- Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: The Global Burden of Disease Study 2015
The Lancet | August 2016 - The contribution of HIV to pregnancy-related mortality: A systematic review and meta-analysis
AIDS | June 2013 - Health systems integration of sexual and reproductive health and HIV services in sub-Saharan Africa: A scoping study
Journal of Acquired Immune Deficiency Syndromes | December 2014 - HIV and the risk of direct obstetric complications: A systematic review and meta-analysis
PLOS One | October 2013 - Sexual and reproductive health and human rights of women living with HIV: A global community survey
Bulletin of the World Health Organization | February 2016 - Global monitoring framework and strategy for the Global Plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive
World Health Organization | April 2012 - Systematic review of the proportion of pregnancy-related deaths attributed to HIV in population-based studies in sub-Saharan Africa
Tropical Medicine & International Health | January 2014 - Towards comprehensive women’s healthcare in sub-Saharan Africa: Addressing Intersections between HIV, reproductive and maternal health
Journal of Acquired Immune Deficiency Syndromes | December 2014 - Barriers and facilitating factors to the uptake of antiretroviral drugs for prevention of mother-to-child transmission of HIV in sub-Saharan Africa: A systematic review
Journal of the International AIDS Society | July 2013 - Community innovation: Achieving sexual and reproductive health and rights for women and girls through the HIV response
UNAIDS | 2011 - Interventions to prevent sexually-transmitted infections, including HIV, among young people in low- and middle-income countries: A systematic review of the published and gray literature
Journal of Adolescent Health | September 2016 - A systematic review of individual and contextual factors affecting ART initiation, adherence, and retention for HIV-infected pregnant and postpartum women
PLOS One | November 2014 - HIV-related stigma as a barrier to achievement of global PMTCT and maternal health goals: A review of the evidence
AIDS and Behavior | September 2013
Recent Publications
Maternal immunisation to improve the health of HIV-exposed infants
National estimates and risk factors associated with early mother-to-child transmission of HIV after implementation of option B+: A cross-sectional analysis
Impact of universal ART for pregnant and postpartum women on ART uptake and retention
Pregnancy outcomes in the era of universal antiretroviral treatment in sub-Saharan Africa (POISE Study)
Challenges and opportunities for outreach workers in the Prevention of Mother to Child Transmission of HIV (PMTCT) program in India
See more recent publications on HIV & AIDS >>
News
Developing an oral contraceptive and HIV-prevention method, in a single pill
Nigeria’s health workers’ strike disrupts maternal care nationwide
Risks to babies of mothers with HIV from three antiretroviral regimens appear to be low
Innovative finger prick test could improve maternal healthcare across the globe
No difference in safety for HIV+ pregnant women deferring TB Tx
Documents & Reports
2018 Monitoring Report for the Every Woman Every Child Global Strategy for Women’s, Children’s and Adolescents’ Health
Family Planning – A global handbook for providers
Saving Mothers’ Lives
Gender and Participation in Option B+ Programs to Prevent Mother-to-Child Transmission of HIV in Malawi and Uganda
Technical Guidance for Prioritizing Adolescent Health
See more HIV & AIDS documents and reports>>
Organizations
- Management Sciences for Health
- Centers for Disease Control and Prevention
- Maternal and Child Health Integrated Program
- Global Network of People Living with HIV
- Harvard AIDS Initiative
- International Community of Women Living with HIV/AIDS
- PEPFAR
- Mothers2Mothers
Videos
- Maternal Health and HIV: Global Priorities for Research and Action
- Women at the crossroads: HIV, reproductive health, maternal mortality, and child health
- Integrating HIV/AIDS and Maternal Health Services
- Maternal Health, HIV, and AIDS: Examining Research Through a Programmatic Lens
- Stigma and Discrimination as Barriers to Achievement of Global PMTCT and Maternal Health Goals
- Reproductive Health Decision-Making among Women Living with HIV
The Role of the MHTF
Featured Resources
- MHTF Quarterly, Issue 2: Maternal Health and HIV
MHTF | February 2014 - Bridging Gaps Between Maternal, HIV and Reproductive Healthcare in Sub-Saharan Africa: Evidence for Action
Journal of Acquired Immune Deficiency Syndromes | December 2014
Meetings & Events
In June 2013, the MHTF collaborated with USAID and the CDC to convene an international technical meeting to discuss emerging evidence linking maternal health and HIV, identify research gaps and consider programmatic implications.
Maternal Health, HIV and AIDS: Examining Research through a Programmatic Lens
In January 2014, as a part of the Advancing Dialogue on Maternal Health Series, the MHTF hosted a panel discussion at the Woodrow Wilson Center to discuss global priorities for maternal health and HIV.
Maternal Health and HIV: Global Priorities for Research and Action
Blog
Blog Series: Maternal Health, HIV & AIDS